Bottom side Sheffield United sprang the biggest surprise of the ongoing Premier League season when they won 2-1 at Old Trafford to knock Manchester United off the top of the table.
On Wednesday evening, Kean Bryan put Sheffield United ahead with a close-range header after 24 minutes, and although former Blades defender Harry Maguire equalised with 25 minutes left to go, Oliver Burke's curling shot 10 minutes later gave his side an unexpected win, reports Xinhua news agency.
The result means Manchester City, who on Tuesday won 5-0 away to West Brom, are the new league leaders.
Meanwhile, Thomas Tuchel's debut as Chelsea coach after being named as Frank Lampard's replacement on Tuesday ended in a 0-0 draw against Wolves at Stamford Bridge.
Chelsea had 79 per cent of the ball, but didn't do enough with it and although Wolves keeper Rui Patricio did well to deny Antonio Rudiger and Callum Hudson-Odoi, Chelsea didn't create enough to take all three points.